RTOG -0525 A Phase III Trial Comparing Conventional Adjuvant Temozolomide with Dose-Intensive Temozolomide in Patients with Newly Diagnosed Glioblastoma
The purpose of this study is to determine if dose-intensifying adjuvant temozolomide during chemoradiation treatment enhances treatment efficacy as measured by overall survival.

RTOG 0413 NSABP B-39 A Randomized Phase III Study of Conventional Whole Breast Radiation vs. Partial Breast Radiation for Women with Stage 0, I or II Breast Cancer
The purpose of this study is to determine whether partial breast irradiation (PBI) limited to the region of the tumor bed following lumpectomy provides equivalent local tumor control in the breast compared to conventional whole breast irradiation (WBI) in the local management of early stage breast cancer.

Phase III Trial of Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer
The purpose of this study is to determine the best hormonal treatment for premenopausal women. Patients are randomized to tamoxifen, tamoxifen plus ovarian suppression function (OFS) or exemestane plus OFS.

Phase II Study to Evaluate Efficacy and Safety of Adjuvant High-Dose Rate Brachytherapy (delivered using the mammosite applicator) as the Sole Method of Radiation Therapy for Selected Women with Stage I Breast Cancer-Small Volume DCIS
The study seeks to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives RT. The study also seeks to assess safety of the mammosite device in this setting, including the quality of life.

Phase III Randomized Trial of Anastrozole vs. Anastrozole and Fulvestrant as First-Line Therapy for PostMenopausal Women with Metastatic Breast Cancer
The study seeks to compare the time to tumor progession in postmenopausal women with metastatic breast cancer treated with anastrozole vs. anastrozole and fulvestrant as first-line therapy.

SWOG S0230 Phase III Trial of LHRH Analog Administration During Chemotherapy to Reduce Ovarian Failure Following Standard Adjuvant Chemotherapy in Early Stage, Hormone Receptor Negative Breast Cancer
The purpose is to compare the rate of premature ovarian failure at two years following standard adjuvant chemo with/without ovarian supression with LHRH analog during chemo in premenopausal women with early stage, hormone-receptor negative breast cancer.

RTOG 0418 A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) to the Pelvis +/- Chemotherapy for Post-Operative Patients with Either Endometrial or Cervical Carcinoma
The purpose of this study is to determine the transportability of IMRT to a multi-institutional setting, and to test the hypothesis that there is a reduction in short-term bowel injury with this regimen compared to standard treatments. Adverse events related to this treatment regimen will be assessed. The rates of local regional control, distant metastasis, disease free and overall survival will be evaluated. Chemotherapy compliance with this regimen for the cervical carcinoma patients will observed.

Intensive Treatment for Intermediate-Risk Relapse of Childhood B-Precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies
The purpose of this study is to determine patient outcomes following high dose combination chemotherapy treatment and to compare higher dose vincristine with compared to standard dose vincristine

A Phase I Dose Escalation Trial of Dendritic Cell-Based Vaccination for Stage IV Melanoma Patients.
The purpose of the study is to assess the dose limiting toxicity for dendritic cells pulsed with autologous tumor lysate and matured using a Dendritic Maturation Cocktail composed of IL-1 beta, IL-6, TNF alpha, and PGE2, injected intranodally with KLH in Stage IV melanoma patients.