A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastoma
The purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.

A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancer
The purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.

SOFT Trial
The purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.

Breast Cancer and Hormone Suppression Study
The research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.

Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)
The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.

Treatment for Metastatic Breast Cancer with Anastrozole with or without Fulvestrant
The purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.

Endometrial or Cervical Cancer Radiation Therapy Study
The purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.

Leukemia Relapse Trial
The purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.

Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).
The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.

Multidisciplinary Study of Right Ventricular Dysplasia (ARVD)
This is a multidisciplinary, multicenter collaborative study to investigate the cardiac, clinical and genetic aspects of arrhythmogenic right ventricular dysplasia (ARVD). The primary goal is to identify 100 patients with definite ARVD and their family members. The study offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and/or localizing the genetic mutation(s) responsible for this disorder.

FREEDOM Trial
The purpose of this study is to compare two different methods of treatment for patients with diabetes mellitus and coronary artery disease in more than one heart vessel. The study seeks to evaluate whether drug-eluding stenting is more or less effective than coronary artery bypass surgery (CABG).

Aortic Valve Surgery in Marfan Patients
The purpose of the trial is to collect information on how patients do after having surgery on their aortic valve and compare the results of those who had their valve replaced to those who had the valve repaired.

Lower Limb Ischemia Study
The purpose of this clinical research is to determine if bone marrow cells that are harvested from your bone and then grown in a lab, or expanded, can be used as a method for treatment of critical limb ischemia in patients with peripheral artery disease.

Growth Hormone Deficiency Study
The purpose of the study is to compare long-term health outcomes in patients who are lacking adult growth hormones.

Endothelial Function in Depressed Patients
The purpose of this study is to determine whether depressed individuals show signs of dysfunction in their blood vessels.

Etanercept Psoriasis Registry
The purpose of this study is to continue to gather and evaluate information on the long-term safety of etanercept in a large number of patients with plaque psoriasis.

ALIAS - Albumin in acute stroke
Many stroke studies have been performed looking for an effective treatment for patients who have suffered an acute ischemic stroke. Thus far, all have failed. This study seeks to determine the effectiveness of albumin versus placebo given intravaenously for stroke patients.

Neck artery blockage
Carotid artery occlusion can be a dangerous factor for TIA and stroke. The study will look at the outcome after brain artery/vein bypass surgery versus best medical therapy.