-
Erfurth FE, Popovic R, Grembecka J, Cierpicki
T, Theisler C, Xia Z-B, Stuart T, Diaz M, Bushweller JH, Zeleznik-Le NJ. MLL
protects CpG clusters from methylation within the Hoxa9 gene, maintaining
transcript expression. Proc. Natl Acad Sci USA, in press, 2007.
-
Popovic R, Erfurth FE, and Zeleznik-Le NJ.
Transcriptional Complexity of the HOXA9 Locus. Blood Cells, Mol Dis., in
press, 2007.
-
Baron BW, Zeleznik-Le NJ, Baron MJ, Theisler C,
Huo D, Krasowski MD, Thirman MJ, Perrella MA, Baron RM, Baron JM. Repression
of the programmed cell death-2 (PDCD2) gene by BCL6—implications for the
pathogenesis of human B- and T-cell lymphomas. Proc. Natl. Acad. Sci. USA
104:7449-54, 2007.
-
Santillan DA, Theisler CM, Ryan AS, Stuart T,
Zhou MM, Alkan S, Zeleznik-Le NJ. Bromodomain and Histone acetyltransferase
domain specificities control MLL leukemia phenotype. Cancer Res 66: 10032-9,
2006.
-
Zeleznik-Le, NJ. Leukemia RNAi: harnessing
the killer within. Blood 106: 3336-3337, 2005.
-
Xia, Z-B, Popovic, R, Chen, J, Theisler, C,
Lorenz, T, Santillan, DA, Erfurth, F, Diaz, MO, Zeleznik-Le, NJ. The MLL
fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B
(p27kip1) expression. Proc. Natl Acad Sci USA 102:14028-33, 2005.
-
Xia, Z-B, Popovic, R, Chen, J, Theisler, C,
Lorenz, T, Santillan, DA, Erfurth, F, Diaz, MO, Zeleznik-Le, NJ. The MLL
fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B
(p27kip1) expression. Proc. Natl Acad Sci USA 102:14028-33, 2005.
-
Popovic R, Zeleznik-Le NJ. MLL: How complex does
it get? J Cell Biochem. 95(2):234-42, 2005.
-
Mujtaba S, He Y, Zeng, L, Yan S, Plotnikova O, Sanchez
R, Zeleznik-Le, NJ, Ronai Z, Zhou MM.
Structural
mechanism of the bromodomain of coactivator CBP in p53
transcriptional activation. Mol. Cell. 13:251-263, 2004.
-
MLL
repression domain interacts with histone deacetylases,
the polycomb group proteins HPC2 and BMI-1, and the
corepressor C-terminal-binding protein. PNAS, 100(14):8342-8347,
2003.
-
Chromatin-related
properties of CBP fused to MLL generate a myelodysplastic-like
syndrome that evolves into myeloid leukemia. The EMBO
Journal, 19:4655-4664, 2000.
-
MLL
is fused to CBP, a histone acetyltransferase, in therapy-related
acute myeloid leukemia with a t(11;16) (q23;p13.3).
Proc Natl Acad Sci, 94:8732-8737, 1997.
-
11q23
translocations split the “AT-hook” cruciform
DNA-binding region and the transcriptional repression
domain from the activation domain of the mixed-lineage
leukemia (MLL) gene. Proc Natl Acad Sci, 91:10610-10614,
1994.
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