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LUCIO MIELE, MD, PhD

  • Song LL, Miele L: Cancer stem cells - an old idea that‘s new again: implications for the diagnosis and treatment of breast cancer. Expert Opin. Biol. Ther. 7: (2007)

  • De Falco M, Cobellis L, Giraldi D, Mastrogiacomo A, Perna A, Colacurci N, Miele L, De Luca A: Expression and
    distribution of Notch protein members in human placenta throughout pregnancy. Placenta 28:118-26 (2007)

  • Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre M-L, Kee BL, Ferrando A, Miele L, Aifantis I: Targeting the NF-kappaB signaling pathway in Notch 1-induced T-cell leukemia. Nat. Med. 13:70-77 (2007)

  • Miele L, Golde T, Osborne B: Notch signaling in cancer. Current Molecular Med. (2006)

  • Osipo C, Miele L: Hedgehog signaling in hepatocellular carcinoma: novel therapeutic strategy targeting hedgehog signaling in HCC. Cancer Biol Ther. 5:238-9 (2006)

  • Curry CL, Reed LL, Nickoloff BJ, Miele L, Foreman KE: Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells. Lab Invest. 86:842-52 (2006)

  • Arumugam TV, Chan SL, Jo D-G, Yilmaz G, Tang S-C, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP: Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine 12: 621-3 (2006)

  • Antico G, Lingen MW, Sassano A, Melby J, Welch RW, Fiore S, Pilon AL, Miele L: Recombinant human uteroglobin/CC10 inhibits the adhesion and migration of primary human endothelial cells via specific and saturable binding to fibronectin. J Cell Physiol. 207:533-61 (2006)

  • Miele L: Notch signaling. Clinical Cancer Res., 12:1074-9 (2006)

  • Miele L, Miao H, Nickoloff BJ: Notch Signaling as a Novel Cancer Therapeutic Target. Curr. Cancer Drug Targets.6:313-23 (2006)

  • Song L, Zlobin A, Ghoshal P, Zhang Q, Houde C, Weijzen S, Jiang Q, Nacheva E, Yagan D, Davis E, Galiegue-Zouitina S, Catovsky D, Grogan T, Staudt LM, Fisher RI, Miele L, Coignet LJ: Alteration of SMRT Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas. Cancer Res. 65:4554-61 (2005).

  • Sarmento LM, Huang H, Limon A, Gordon W, Fernandes J, Tavares MJ, Miele L, Cardoso AA, Classon M, Carlesso N: Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1degradation. J Exp Med. 202:157-68 (2005)

  • Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE: Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi’s sarcoma tumor cells. Oncogene24:6333-44 (2005)

  • Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA: Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6:680-8 (2005)

  • Nickoloff BJ, Hendrix MJ, Pollock PM, Trent JM, Miele L, Qin J-Z: Notch and NOXA-Related Pathways in Melanoma Cells. J. Invest. Dermatol. 10:95-104 (2005)

  • Qin J-Z, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock PM, Trent JM, Hendrix MJ, Rizzo P, Miele L, Nickoloff BJ: Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res. 65:6282-93 (2005)
     

 

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 Last reviewed: Nov. 16, 2007