Song LL, Miele L: Cancer stem cells - an old idea
that‘s new again: implications for the diagnosis and treatment of
breast cancer. Expert Opin. Biol. Ther. 7: (2007)
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De Falco M, Cobellis L, Giraldi D, Mastrogiacomo A,
Perna A, Colacurci N, Miele L, De Luca A: Expression and
distribution of Notch protein members in human placenta throughout
pregnancy. Placenta 28:118-26 (2007)
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Vilimas T, Mascarenhas J, Palomero T, Mandal M,
Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre
M-L, Kee BL, Ferrando A, Miele L, Aifantis I: Targeting the NF-kappaB
signaling pathway in Notch 1-induced T-cell leukemia. Nat. Med.
13:70-77 (2007)
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Miele L, Golde T, Osborne B: Notch signaling in
cancer. Current Molecular Med. (2006)
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Osipo C, Miele L: Hedgehog signaling in
hepatocellular carcinoma: novel therapeutic strategy targeting
hedgehog signaling in HCC. Cancer Biol Ther. 5:238-9 (2006)
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Curry CL, Reed LL, Nickoloff BJ, Miele L, Foreman KE:
Notch-independent regulation of Hes-1 expression by c-Jun N-terminal
kinase signaling in human endothelial cells. Lab Invest. 86:842-52
(2006)
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Arumugam TV, Chan SL, Jo D-G, Yilmaz G, Tang S-C, Cheng A,
Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X,
Miele L, Magnus T, Poosala S, Granger DN, Mattson MP: Gamma
secretase-mediated Notch signaling worsens brain damage and
functional outcome in ischemic stroke. Nature Medicine 12: 621-3
(2006)
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Antico G, Lingen MW, Sassano A, Melby J, Welch RW,
Fiore S, Pilon AL, Miele L: Recombinant human uteroglobin/CC10
inhibits the adhesion and migration of primary human endothelial
cells via specific and saturable binding to fibronectin. J Cell
Physiol. 207:533-61 (2006)
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Miele L: Notch signaling. Clinical Cancer Res.,
12:1074-9 (2006)
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Miele L, Miao H, Nickoloff BJ: Notch Signaling as a Novel Cancer Therapeutic Target.
Curr. Cancer Drug Targets.6:313-23 (2006)
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Song L, Zlobin A, Ghoshal P, Zhang Q, Houde C, Weijzen S, Jiang Q, Nacheva E,
Yagan D, Davis E, Galiegue-Zouitina S, Catovsky D, Grogan T, Staudt LM,
Fisher RI, Miele L, Coignet LJ: Alteration of SMRT Tumor Suppressor Function in
Transformed Non-Hodgkin Lymphomas. Cancer Res. 65:4554-61 (2005).
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Sarmento LM, Huang H, Limon A, Gordon W, Fernandes J, Tavares MJ, Miele L,
Cardoso AA, Classon M, Carlesso N: Notch1 modulates timing of G1-S progression by
inducing SKP2 transcription and p27 Kip1degradation. J Exp Med. 202:157-68 (2005)
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Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE: Gamma
secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi’s sarcoma
tumor cells. Oncogene24:6333-44 (2005)
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Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH,
Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L,
Golde TE, Miller SD, Osborne BA: Inhibitors of gamma-secretase block in
vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
Nat. Immunol. 6:680-8 (2005)
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Nickoloff BJ, Hendrix MJ, Pollock
PM, Trent JM, Miele L, Qin J-Z: Notch and NOXA-Related Pathways in
Melanoma Cells. J. Invest. Dermatol. 10:95-104 (2005)
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Qin J-Z, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock
PM, Trent JM, Hendrix MJ, Rizzo P, Miele L, Nickoloff BJ: Proteasome
inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer
Res. 65:6282-93 (2005)
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