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Manuel O. Diaz, M.D.

  • Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, Wei W, Xia Z, Diaz M, Akira S, Zhang
    J. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med.
    2008 205(7):1611-9.

  • Chen J, Santillan DA, Koonce M, Wei W, Luo R, Thirman MJ, Zeleznik-Le NJ, Diaz MO. Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer Research 68:6199-6207, 2008.

  • Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc. Natl Acad Sci USA. 105:7517-7522, 2008.

  • The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33. Epub 2005 Sep 16.

  • Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia (published online ahead of print) Sept. 2005

  • MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. PNAS, 100(14):8342-8347, 2003.

  • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division. Cancer Research, 63:1377-1381, 2003.

  • A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Dev Genes Evol, 212:107-113, 2002.

  • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Research, 61:4550-4555, 2001.

  • Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Molecular and Cellular Biology, 21(10):3589-3597, 2001.

  • Id-1 delays senescence but does not immortalize keratinocytes. The Journal of Biological Chemistry, 275(36):27501-27504, 2000.

  • MLL2: A new mammalian member of the trx/MLL family of genes. Genomics, 59:187-192, 1999.

  • Apoptosis in proliferating, senescent, and immortalized keratinocytes. The Journal of Biological Chemistry, 274(33):23358-23367, 1999.

 

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