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Manuel O. Diaz, M.D.

  • The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33. Epub 2005 Sep 16.

  • Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia (published online ahead of print) Sept. 2005

  • MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. PNAS, 100(14):8342-8347, 2003.

  • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division. Cancer Research, 63:1377-1381, 2003.

  • A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Dev Genes Evol, 212:107-113, 2002.

  • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Research, 61:4550-4555, 2001.

  • Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Molecular and Cellular Biology, 21(10):3589-3597, 2001.

  • Id-1 delays senescence but does not immortalize keratinocytes. The Journal of Biological Chemistry, 275(36):27501-27504, 2000.

  • MLL2: A new mammalian member of the trx/MLL family of genes. Genomics, 59:187-192, 1999.

  • Apoptosis in proliferating, senescent, and immortalized keratinocytes. The Journal of Biological Chemistry, 274(33):23358-23367, 1999.

 

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