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Mitchell Denning, PhD

  • D’Costa, A. M., Robinson, J. K., Maududi, T., Chaturvedi, V., Nickoloff, B. J., and Denning, M. F.: The pro-apoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene, 25: 378-86, 2006

  • Sitailo, L. A., Tibudan, S. S., and Denning, M. F.: The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. J. Biol. Chem. 281: 29703-10, 2006

  • D’Costa, A. M. and Denning, M. F.: A caspase resistant mutant of PKC-d protects keratinocytes from UV-induced apoptosis. Cell Death Differ., 12: 224-232, 2005.

  •  Sitailo, L. A., Tibudan, S. S., and Denning, M. F.: Bax activation and induction of apoptosis in human keratinocytes by the protein kinase C d catalytic domain. J. Invest. Dermatol., 123: 434-443, 2004.

  • Activation of Caspase-9 is required for UV-induced apoptosis of human keratinocytes. The Journal of Biological Chemistry, 277(22):19346-19352, 2002.

  • Caspase activation and disruption of mitochondrial membrane potential during UV-radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death and Differentiation, 9:40-52, 2002.

  • Activation of protein kinase C triggers irreversible cell cycle withdrawal in human keratinocytes. Journal of Investigative Dermatology, 119:1282-1289, 2002.

 

 

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